Blood Concentrations of Amitriptyline and Its Metabolite in Rats after Acute Oral Administration of Amitriptyline
نویسندگان
چکیده
منابع مشابه
Acute polyradiculoneuropathy after amitriptyline overdose.
A 53 year. old depressive woman had been taking' amitriptyline 75 mg and lorazepam 2-5 mg daily in January 1984. At the beginning of February she took soluble amitriptyline 800 mg in a suicide. attempt. She became comatose, with generalised seizures, mydriasis, and urinary retention; her muscle stretch reflexes were normal, blood pressure 90/50 mm Hg, body temperature 370C, and' pulse 100 beats...
متن کاملPlasma amitriptyline level after acute administration, and driving performance in healthy volunteers.
AIMS Amitriptyline triggers the impairment of cognitive and motor functions and has been confirmed to have harmful effects on driving performance. Although interindividual differences in plasma concentration may cause variations in driving performance, the relationship between plasma amitriptyline concentration and its effect on driving performance has not been completely elucidated. Thus, the ...
متن کاملPhotosensitized Degradation of Amitriptyline and Its Active Metabolite Nortriptyline in Aqueous Fulvic Acid Solution.
Amitriptyline is a frequently prescribed tricyclic antidepressant. Although amitriptyline and its active metabolite, nortriptyline, have been widely detected in natural waters, their environmental fate due to photodegradation is poorly understood. Here we describe a study conducted to investigate the photodegradation of amitriptyline and its active metabolite under simulated sunlight. Neither a...
متن کاملHypersensitivity syndrome caused by amitriptyline administration.
Adverse cutaneous manifestations are among the most common side effects associated with psychotropic drugs. Skin reactions due to amitriptyline (a tricyclic antidepressant agent) include rashes and hypersensitivity reactions (for example, urticaria and photosensitivity) as well as hyperpigmentation. Hypersensitivity syndrome is a specific severe idiosyncratic reaction causing skin, liver, joint...
متن کاملPulmonary disease after amitriptyline overdosage.
of amitriptyline is reported.The disease process was accompanied by noticeable loss of lung compliance, and a gross diffusion defect at alveolar level. It seems unlikely that the course was that of an aspiration or bronchopneumonia, and clinically and pathologically it resembled the changes seen in surfactant deficiency. It is suggested that amitriptyline in overdosage may interfere with the pr...
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ژورنال
عنوان ژورنال: Journal of Analytical Toxicology
سال: 2000
ISSN: 1945-2403,0146-4760
DOI: 10.1093/jat/24.4.271